VTS
- 1:
VTS Home. - 2: Hilfe.
- 3: Helpdesk des kiz.
- 1: Portalsuche.
- 2: Neuerscheinungen.
- 3: Volltextsuche.
- 4: Metadatensuche.
- 5: Browsing.
VTS-ID/8239
Lizenz
Bitte zitieren Sie dieses Dokument als
URL: http://vts.uni-ulm.de/doc.asp?id=8239
URN: urn:nbn:de:bsz:289-vts-82391
Metadaten
Optionale Metadatenformate: RIS-Export | oai_dc | XMetaDissPlus(v1.3) | xMetaDissPlus(v2.0)
| Titel | Expression und prognostische Bedeutung von Caspase-8 in Kolonkarzinomen des UICC-Stadiums II und III |
| Autor / Hrsg. |
Herter, Ines
|
| Dokumentart | Dissertation |
| Institution | Universität Ulm. Medizinische Fakultät |
| DDC-Sachgruppe |
Medicine & health (ddc:610)
|
| Schlagwörter (): Schlagwortschema |
Apoptose (custom)
Apoptosis (SWD) Caspase 8 (MeSH) Caspasen (SWD) Colonic neoplasms (MeSH) Colonkrebs (SWD) Kolonkarzinom (custom) |
| Sprache | deutsch |
| Jahr der Erstellung | 2011 |
| Signatur | W: W-H 13.081 |
| VTS-Veröffentlichung | 14.11.2012 |
| Statistik |
151 Zugriffe seit 14.11.2012
|
| Abstract | Caspase-8 is an important factor in the execution of death signals. To study the prognostic influence in colon carcinoma, expression of caspase-8 was determined by immunhistochemistry in normal colon mucosa and R0-resected stage II/III colon carcinomas (n 124) using a semiquantitative score. Staining results were correlated with disease-free survival by Kaplan-Meier estimates, and multivariate Cox analyses were performed. In colon carinomas, there is considerabele variability in the expression of the proapoptotic factor, although complete loss of caspase-8 is rare. High-level expression of caspase-8 in a majority of tumor cells was significantly associated with adverse prognosis. The influence of caspase-8 expression was mainly seen in patients with stage III colon carcinoma. After adjusting for confounding factors in a multivariate Cox analysis, caspase-8 has no predicting influence on disease-free survival. Diese Dissertation beruht auf dem Aufsatz in: International journal of cancer 127 (2010), H. 4, S. 873 - 880, http://onlinelibrary.wiley.com/doi/10.1002/ijc.25111/abstract |
Dateien
Anzahl der Teildokumente: 1
| Teildokument | Format | Zertifikat / Hash |
|---|---|---|
| vts_8239_12064.pdf Dateigröße: 511 kByte 50 S. | application/pdf | PGP-Signatur: DH/DSS Zertifikat MD5-Hash: 09b29b0ac8dd1aac36821c0281242d75 |